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Nutricia Press Release October 2012
Nutricia will invest in a new medical nutrition study, targeting patients at the earliest stage of Alzheimer’s disease.
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About Souvenaid
Souvenaid contains a unique patented combination of nutritional precursors (docosahexaenoic acid, eicosapentaenoic acid, uridine monophosphate, and choline) and cofactors (phospholipids, folic acid, vitamins B, C and E, and selenium) designed to support synapse formation.
What is Souvenaid?
Souvenaid is a FSMP for patients with early Alzheimer’s disease, a progressive neurological disease characterised by amyloid plaque formation, neurofibrillary tangles and synapse loss. The concept behind Souvenaid is to provide a combination of certain nutrients to support synapse formation in early patients with Alzheimer’s disease.
Product information
Souvenaid has been designed as a FSMP for the dietary management of early Alzheimer's disease and intended to be used under medical supervision. The concept is under development and is scheduled to be launched in selected countries in 2012. It has been developed by scientists at Nutricia Advanced Medical Nutrition, a specialised business unit of Danone.
Preclinical studies
In preclinical experiments, enhancing the diet with certain nutrients [5] was shown to increase dendritic spines, synaptic proteins and neurite outgrowth [5-7], all prerequisites for synapse formation.
Additional information
Additional information on the memory tests used in Souvenaid trials.
S Connect
S-Connect was a 24-week randomised, controlled, double-blind trial in 527 patients with mild-to-moderate Alzheimer’s disease with a MMSE score ranging from 14-24.
Souvenir II
Souvenir II was a randomised, controlled, double-blind trial involving 259 drug-naïve patients across 27 centres in six European countries (the Netherlands, Germany, France, Belgium, Italy and Spain).
Souvenir I
Souvenaid was first studied in patients with Alzheimer's disease in a randomised controlled trial (Souvenir I) [1].
Souvenaid clinical trial programme
A clinical trial programme is underway to seek to establish the extent to which Souvenaid can improve memory performance in patients at various stages of Alzheimer's disease [1-4].
Research program
Souvenaid has been designed as a FSMP for the management of early Alzheimer's disease and must be used under medical supervision. The concept is under development and is scheduled to be launched in selected countries in 2012. It has been developed by scientists at Nutricia Advanced Medical Nutrition, a specialised business unit of Danone.
The ability of nutrients to support membrane and synapse formation, and the hypothesis that combinations of certain nutrients could provide clinically relevant benefits to patients with Alzheimer’s diesase has formed the scientific rationale for the development of Souvenaid, the result of over 10 years of research at Nutricia Advanced Medical Nutrition in the Netherlands, following preclinical work conducted by scientists at the Massachusetts Institute of Technology (MIT).
What is the role of nutrients in Alzheimer’s disease?
An increasing amount of evidence from epidemiological studies, clinical trials and preclinical research shows that nutrients can to play an important role in the pathophysiology and progression of Alzheimer’s disease.
How does Souvenaid work?
Souvenaid is designed to meet the specific nutritional needs of early Alzheimer's patients.
Why is synapse formation important?
Loss of synapses is one of the hallmarks of Alzheimer’s disease and is associated with impaired memory and other cognitive deficits [1].
What is the role of Souvenaid?
Souvenaid has been developed for patients with early Alzheimer’s disease by providing a combination of nutrients specifically designed to support synapse formation.
What is a Food for Special Medical Purposes (FSMP)?
FSMP is for the dietary management of patients affected by a specific disease, disorder or medical condition.
How does Souvenaid address nutritional needs?
Souvenaid contains a unique, patented combination of nutrients designed to support synapse formation. This unique combination of nutrients is known under the name Fortasyn Connect™.
What is the rationale for nutrients to support synapse formation?
There is a strong body of literature supporting the belief that patients with Alzheimer’s disease have specific nutritional needs [6-13].
Why is memory relevant in early AD?
Loss of synapses is one of the hallmarks of Alzheimer’s disease and is associated with impaired memory and other cognitive deficits [1-3]. Memory loss is an early event in the progression of Alzheimer’s disease.
What is Souvenaid?
Souvenaid is a new concept in medical nutrition for patients with early Alzheimer’s disease (AD), a progressive neurological disease characterised by amyloid plaque formation, neurofibrillary tangles and synapse loss. The concept behind Souvenaid is to provide a combination of certain nutrients to support synapse formation and function in patients with early Alzheimer’s disease.
Souvenaid:
- Contains a unique, patented combination of nutrients designed to support synapse formation
- Addresses specific nutritional needs that are understood to exist in patients with early Alzheimer’s disease
- Is intended to be used under medical supervision
Nutricia Press Release April 2012
Nutricia Advanced Medical Nutrition supports EU-led health action to address undernutrition in older persons and patients
Nutricia Advanced Medical Nutrition, the specialised healthcare unit of Danone, will serve as a partner in the implementation stage of the Active and Healthy Ageing (AHA) project, the EU-led initiative intended to help older Europeans enjoy a more active and healthy life.
FAQ Nutilis Complete
Frequently asked questions about Nutilis Complete.
FAQ Nutilis Aqua
Frequently asked questions about Nutilis Aqua.
FAQ Nutilis Clear
Frequently asked questions about Nutilis Clear.
FAQ Nutilis Powder
Frequently asked questions about Nutilis Powder.
The importance of consistent viscosities
For people with swallowing difficulties it is important that thickened food and fluids maintain their consistency in the mouth.
Managing dysphagia
The care of a patient with dysphagia involves a multidisciplinary team of specialists. There are different ways to manage dysphagia depending on the underlying diseases and severity of the dysphagia: medical, surgical and/or behaviour management[1].
Consequences
Dysphagia has tremendous impact on the quality of life of the patient and can potentially be fatal [1]. Patients with dysphagia are at high risk of aspiration, malnutrition and dehydratation [2,5,6]
Presentation Prof. Boirie, ESPEN 2010 (Part 2)
Modulation of muscle anabolism by dietary protein in elderly.
Presentation Prof. Boirie, ESPEN 2010 (Part 1)
Modulation of muscle anabolism by dietary protein in elderly.
Interview with Prof Dr. Yves Rolland about Sarkopenie
Prof. Dr. Yves Rolland on Sarcopenia
ESPEN 2010
Presentation Prof. Rolland, ESPEN 2010
A clinical view on increased problems of functional limitation and mobility disability.
Videos
Watch interviews and presentations.
Frailty and malnutrition
Frailty is recognized as a geriatric syndrome[1] and describes old people at high risk of adverse health outcomes. Due to a decline in physiological reserves, frail old people confronted by stress might be or are at high risk of disability, illness, hospitalization, or mortality[2].
Presentation Prof. Boirie, ESPEN 2010 (Part 2)
Modulation of muscle anabolism by dietary protein in elderly.
Presentation Prof. Boirie, ESPEN 2010 (Part 1)
Modulation of muscle anabolism by dietary protein in elderly.
Interview with Prof Dr. Yves Rolland about Sarcopenia
Prof. Dr. Yves Rolland on Sarcopenia
ESPEN 2010
Presentation Prof. Rolland, ESPEN 2010
A clinical view on increased problems of functional limitation and mobility disability.
Videos
Watch interviews and presentations.
Screening
Assessment of muscle mass (DXA; BIA), strength (handgrip strength) and function (SPPB, gait speed, get-up-and-go test) are advised to diagnose sarcopenia.
Exercises
“No pharmacological or behavioral intervention to reverse sarcopenia has proven to be as efficacious as resistance training” [1].
Nutritional Intervention
Evidence suggests that leucine-enriched essential amino acid (EAA) supplementation improves muscle mass, strength and function. [3,4,5,6,7]
Management Options
Considerable evidence suggests that sarcopenia is a reversible cause of disability and could benefit from intervention, especially during the early stages of the condition [1].
Current evidence suggests that physical exercise and nutritional therapy are key to managing and reducing the risk of sarcopenia [1,2].
Clinical consequences of sarcopenia
A grave change associated with aging is progressive decline in skeletal muscle mass, a downward spiral that may lead to decreased strength and functionality [1].
Causes of sarcopenia
Muscle loss in the elderly leads to a decline in mobility and independence. [1]
Neocate Range
Neocate is a amino acid based formula that has a specialised age-adapted range. In Europe Neocate is a food for special medical purposes and should be used in consultation with a healthcare professional.
Information for parents
You can find vast parent-friendly information on cow’s milk allergy, such as how it presents in infants, how healthcare professionals diagnose the condition and also helpful online tools by going directly to www.neocate.com
Dietary management CMA
Infants with confirmed cow’s milk allergy should be treated by complete exclusion of cow’s milk protein (CMP) [6].
Cow’s Milk Allergy (CMA)
Cow’s Milk Allergy (CMA) is an immune response to cow’s milk protein. CMA can present with a variety of symptoms generally affecting the respiratory tract (e.g. sneezing, wheezing), the skin (e.g. skin rash, eczema) and the gastrointestinal tract (e.g. vomiting, diarrhoea, constipation) [2].
Metabolic Control
The Metabolic Control category - as part of Nutricia Advanced Medical Nutrition - has the vision to be the leading and trusted partner for life to all metabolic patients worldwide and their families.
Innovation
Reformulation of Nutrison portfolio
Six variants of the Nutrison portfolio are reformulated aiming to further contribute for a better tolerability by minimizing some typical complications in tube fed patients. New Nutrison has a unique formulation that targets both upper and lower digestive complications.
FAQ
Frequently asked questions about Nutrison.
FAQ
Facts & Figures
The Danone company's extensive Research and Development organisations comprise 1250 scientists worldwide; More than 590 scientists are exclusively devoted to Nutricia Specialised Nutrition (both Baby Nutrition and Medical Nutrition), with 60 PhDs
Medical background
The need for age/weight-adapted feeds
Nutrient requirements differ between younger and older children; therefore Nutricia has designed feeds to meet the needs of these groups (by age/weight). A study by Evans et al. investigated formula suitability for children aged 7-12 years on home enteral tube feeding by comparing the nutrient intake of three different feeds; a paediatric feed (PF) for 1-6 year olds (9-20kg bodyweight), an adult feed (AF), and a feed (NutriniMax) for children aged 7-12 years (21-45kg body weight).[1]
Short bowel syndrome
Short bowel syndrome (SBS) is the consequence of massive small-bowel resection resulting in severe nutrient malabsorption that occurs due to loss of mucosal surface area.[1] It is seen after surgical intervention for long-segment necrotising enterocolitis, mitgut volvulus, acute ischemic injury, small-bowel aganglionosis and other conditions involving the small bowel.[1]
Congenital heart disease
Congenital heart disease (CHD) is a defect in the structure of the heart and its large blood vessels which is present at birth.[1] Growth in children with congenital heart disease is often compromised. Cardiac malformations are responsible for undernutrition, which may range from mild undernutrition to severe failure to thrive. Undernutrition may then significantly undermine the outcome of corrective surgical operations and postoperative recovery.
Critical Care
A significant proportion of critically ill children admitted to the paediatric intensive care unit (PICU) present with nutritional deficiencies. Undernourished hospitalised patients have a higher rate of complications, increased mortality, longer length of hospital stay, and increased hospital costs.[1]
Inflammatory bowel diseases (IBD)
IBD (Crohn’s disease, ulcerative and other colitis) continue to be a common cause of morbidity which impact on the child’s quality of life. Crohn's disease tends to present in older children and young adults, with another peak incidence in the fifties to seventies, although the disease can occur at any age.[1,2] Crohn's disease affects between 400,000 to 600,000 people in North America.[3] Prevalence estimated for Northern Europe have ranged from 27–48 per 100,000.[4] Ulcerative colitis occurs in 35–100 people in every 100,000 in the United States.[5,6]
Others
Inflamatory Bowel Diseases, Critical Care, Congenital Heart Disease, or Short Bowel Syndrome are conditions that can also lead to special nutritional needs.
Maldigestion / malabsorption
Maldigestion describes the inability of an individual to digest food in the gut [1] - malabsorption is the inability to absorb nutrients which have been digested from food through the gut.[1]
Dysphagia
Dysphagia refers to any disorder in the swallowing process that does not allow food or fluid to pass safely from the mouth to the stomach. It is a common condition in many patient types, and might lead to aspiration, malnutrition and dehydratation.
Product list
Usage
Fortimel continues to be developed in different compositions, flavours and textures to meet specific needs, optimize compliance, and cater for individual preferences. To encourage patients who have little appetite, many products are available in small volume formats. All our products are ready-to-use.
FAQ
Frequently asked questions about Nutilis products.
How does it work?
NutriniDrink is a nutritionally complete, energy dense (150kcal/100ml), ready-to-use milk shake style range of drinks.
FAQ
Medical background
There is a sound rationale for the inclusion of fibre in enteral feeds, for a number of reasons.
Nutrition and Diseases
Many diseases and conditions can be addressed with specialised nutrition as a complement to drug therapy, either directly or because nutritional support helps patients to find the strength they need to battle their condition.
Role of Medical Nutrition
Medical Nutrition is increasingly understood as a useful and sometimes essential component in the management of patient health. Medical nutrition is not intended to treat disease, but is widely used by docotors and dieticians as a complement to traditional drug therapies, and as a means to support patients to better fight their condition or maintain their strength.
How does Nutilis work?
Nutilis products are designed to thicken food and fluids or are already pre-thickened to an optimum viscosity in order to ensure a safer swallow for dysphagia patients.
Product list
All Nutilis products have Amylase resistant features for a safer swallow.
Indication
Nutilis products are indicated for dysphagia patients requiring food and fluids texture modification and/or at risk of malnutrition and dehydration.
How does it work?
Children are different and so are their nutritional needs. Therefore the Nutrini range has been especially designed to meet the nutritional needs of both younger (Nutrini; 9-20kg body weight) and older children (NutriniMax; 21-45kg body weight).The Nutrini range also contains a whey-dominant formulation for improved tolerance and protein balance and a docosahexaenoic acid (DHA)-dominant LCP blend to help maintain mental function and prevent deficiency.
FAQ
Medical background
Infatrini has been shown to be well-tolerated in infants with growth failure, to improve energy and nutrient intakes, as well as weight gain and linear growth.[1-5]
How does it work?
Infatrini is an energy, protein and nutrient dense formula. It contains higher levels of energy (100kcal/100ml), protein (2.6g/100ml) and micronutrients than standard infant formulae to ensure adequate intakes of all nutrients in infants with increased needs, or in those with limited intakes. Infatrini is suitable as a sole source of nutrition and contains a unique mix of prebiotics, nucleotides and a fat blend that contains long-chain polyunsaturated fatty acids (LCPs).
Product list
Infatrini is a Food for Special Medical Purposes for use under medical supervision. Infatrini is a nutritionally complete, energy dense, ready to use feed for the dietary management of infants (from birth up to 18 months or 8kg in body weight) with faltering growth, or who have increased nutritional requirements and/or require fluid restriction. Infatrini is suitable as a sole source of nutrition and contains prebiotics, nucleotides and a unique fat blend that contains LCPs.