SYNEO: Stronger than you think

Designed to support the developing immune system. Managing food allergy symptoms is a top priority. But when you look a little deeper, you’ll see that many of your cows’ milk allergy (CMA) patients have an altered gut microbiota – called gut microbiota dysbiosis1-5


What if you could go beyond symptom resolution and do more to support immune system development? With SYNEO you can – because SYNEO is stronger than you think.

Whatever your patients do next, support their immune system – don’t compromise

All kids want to explore the world with wild abandon – so it’s crucial to support immune system development. Our SYNEO formulations are the only cows' milk allergy range to contain our unique mix of preand probiotics, which work together to rebalance the gut microbiota to support immune system development and long-term health6-10.


SYNEO is backed by 10 years of research in 1,500 infants. SYNEO balances the gut microbiota, bringing it closer to that of healthy, breastfed babies, with fewer reports of antibiotic use, infections, and hospitalizations due to infections (based on evaluation of adverse events in Neocate SYNEO studies)6-9.

It’s time to take a fresh look at SYNEO – and go beyond symptom resolution. 

Show gut dysbiosis what you’re made of

It is becoming increasingly clear that the gut plays a central role in our overall health; specifically, the complex system of micro-organisms that live within the gut, collectively known as the gut microbiota11. When the delicate balance of gut microbiota is disturbed during early life, it may increase the risk of health problems like allergy, obesity, heart and vascular disease, diabetes and hypertension12,13.

SYNEO formulations are the only hypoallergenic formulas that have been proven to rebalance the gut microbiota, with the help of specialized pre- and probiotics for infants


Researched with rigor

In addition to efective symptom resolution and proven hypoallergenicity, SYNEO formulations (only applicable for the formulas for the dietary management of cows' milk allergy) have been clinically proven to rebalance the gut microbiota, to support the developing immune system.

You can always be confident the power of SYNEO is supported by a strong clinical trial programme6-10,14.

Three clinical studies show that synbiotics positively influence the gut microbiota of cows' milk allergic infants6,7,9 bringing it closer to that of healthy breastfed infants9.

Inspired by the microbiota-modulating properties of breast milk

Breast milk is the best possible nutrition for infants – it contains everything they need for healthy growth and development. SYNEO formulations are designed to be closer to the synbiotic gut microbiota modulator factors of breast milk than other hypoallergenic formula. SYNEO contains our unique blend of– probiotics and prebiotic oligosaccharides. The prebiotic oligosaccharides mimic the diversity, quantity, and functionality of human milk oligosaccharides (HMOs) in breast milk6-8.

Go beyond cows' milk allergy symptom resolution – be a force for a resilient immune system

Whether your patients have mild/moderate or severe/complex cows' milk allergy, there's a SYNEO product that’s right for them. The simple flow chart below will help you navigate your way to the cows' milk allergy management formula that best suits your cows' milk allergy patients.

There are two prebiotic mixtures used in our range for the dietary management of CMA. Both mixtures are unique and consist of short-chain and long-chain oligosaccharides. Aptamil Pepti SYNEO contains scGOS/lcFOS (9:1) and Neocate SYNEO contains scFOS/lcFOS (9:1). The probiotic Bifodobacterium breve M-16V is present in both formulas.

Aptamil Pepti SYNEO and Neocate SYNEO are Food for Special Medical Purposes, for use under medical supervision.

See for yourself how SYNEO is stronger than you think

Visit your local Nutricia site for more information

  1. Van der Aa LB, et al. Clin Exp Allergy, 2010;40:795–804.
  2. Abrahamsson TR, et al. J Allergy Clin Immunol, 2012;129:434-40, e1-2.
  3. West CE, et al. J Allergy Clin Immunol, 2015;135(1):3-1.
  4. Kim BJ, et al. Allergy Asthma Immunol Res, 2014;6(5):389–400.
  5. Azad MD, et al. BJOG, 2016;123(6):983-93.
  6. Burks A, et al. Pediatr Allergy Immunol, 2015 ;26(4) :316-22.
  7. Fox AT, et al. Clin Transl Allergy, 2019 ;9 :5.
  8. Presto study, submitted for publication.
  9. Candy D, et al. Pediatri Res, 2018;83(3): 677-86.
  10.  Van der Aa LB, et al. Clin Exp Allergy, 2010;40:795–804.
  11.  Jandhyala SM, et al. World J Gastroenterol, 2015;21(29); 8787–803.
  12.  Collado MC, et al. Pediatr Res, 2015;77,182-8.
  13.  Lee YY, et al. J Paediatr Child Health, 2017;53,1152-8.
  14.  Wopereis, et al. Abstract presented at EAACI-FAAM, October, 2020.

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